In contrast, the MK-7 form remains bioactive in the body for about 3 days this is one of the key reasons why you need so much less just 120 mcg has been shown in the research to be effective for MOST people. Hi Lara, Note that the COMB study was conducted by Dr. GenUIs (not Genius)I have contacted his office regarding the type of exercise that was used by patients in the study and was surprised to learn that he recommends jumping, running, or jogging (exercises that are typically contraindicated for osteoporotic patients), working up to 300 repetitions. These exercises can help you strengthen the muscles that support your spine, so can help you to decompress and re-elongate your spine. I just ran a PubMed search for Meunier PJ 2002 again, and the article appeared I have no idea why it did not come up for me when I checked earlier. Also, you need to check to see if the drug(s) you are taking interact adversely. I was attempting to simplify but see that just increases potential for confusion. We already can get this information for some things for example, my genetic inheritance includes a SNP that makes my vitamin D receptors less able to latch on to vitamin D, so I need much more vitamin D than the average person to get my levels into a healthy range. OPG is a decoy for RANKL and binds to RANK, decreasing osteoclast production; strontium increases OPG production. My bones have been in excellent shape now for more than 6 years (within 6 months after I started taking AlgaeCal Plus), but I continue to take a half dose (1 capsule) of Strontium Boost daily to ensure they stay healthy! Answer (1 of 3): It is very important to take your levothyroxine at least 30-60 minutes before breakfast, on an empty stomach. My question has to do with breast cancer. Subjects in all three plans had an increase in BMD: Plan 1= +1.20%, Plan 2= + 0.33%, and Plan 3= +2.5%. Is it safe to take it. Conventionally grown vegetables have been shown to contain far less of many minerals, so if you are not eating organic, all bets are off here. The stomach is a very acidic environment, but after eating, your stomach becomes less acidic. That makes sense about the calcium dosage. Need Help? I came off and just took calcium supplements. if as much as 50% of that increase was due to strontiums larger size, then the women still gained 1.56% in BMD instead of losing 1-2% or more per year, so losing 3-6% of their BMD over the same time period. Hi Sara, Osteoid: Osteoblasts secrete osteoid, the unmineralized portion of the bone matrix, as the first step in their bone building process. Gan To Kagaku Ryoho. The element strontium is present in natural strontium salts. That's why our formula contains over 12 different supplements in one. For example, if your diet is giving you 400 mg of calcium each day, then you need to take 800 mg of calcium in the form of a supplement. There is a still cutting edge but available blood test to check to see how well you are doing at this they can check your blood levels of uncarboxylated osteocalcin (ucOC). I have been taking strontium citrate for 10 years. Charlotte. I have been taking AlgaeCal Plus for over 10 years (3-4 capsules daily). http://ukpmc.ac.uk/theses/ETH/2476. One caveat here if you eat tuna PLEASE purchase tuna that has been checked for mercury content! Hello Lara, I have learned a great deal about strontium citrate and the other bone supplements reading the answers to the questions posted. Based on your previous response to me I should probably add to my K2 amount. study, the exercises were conducted during short breaks from work at the office. Biopsies of my colon showed lymphocytic colitis which is sometimes related to medication use. Ive written quite a bit about BHRT (which I am on and have been on for more than 10 years now) you can read many these articles on Smart Publications website. Osteoporos Int. As I explained, calcium and strontium compete for absorption, and calcium will always be preferentially absorbed. Saquinavir. Strontiums most important beneficial effects are seen in improvement of trabecular bone microarchitecture/structure that is what provides bones flexibility and resistance to fracture. We are lucky here in Australia, our dairy is virtually all green-grass grazing, much of our beef is too, especially when obtained from the local butcher and not the supermarket; can get free-range chickens cooked to perfection locally, lamb is always green-grass grazed, but pork is a mystery due to production methods, and if I choose to eat seasonal fruit and vegetables organic, I am happy as a lark. Now this really bothers me I am 47 and cant think of not taking any calcium supplement. Taking 1 capsule several times a day will be a bit of a hassle as you must take strontium several hours before or after consuming calcium, so it would be easier to take 2-3 at once. The X-ray microanalysis method provided a semiquantitative evaluation of the amount of strontium taken up by the bone mineral substance, and its localization. This is the dose I now take myself as my bones have now been in perfect shape for several years thank you, AlgaeCal Plus and Strontium Boost! In one of the studies he notes, women with the lowest levels of DHEA had double the risk of fracture as women with the highest levels. This emphasizes the value, as antiosteoporotic treatment, of SR, which is safe at the bone mineral level. Hi Dennis, Interesting that my calcium was high and I have never taken calcium supplements until quite recently. The study to which you sent me a link is the only human study I could find, but recent papers indicate lactoferrin may be quite helpful. A radioactive form of strontium may kill some cancer cells. Finally, plasma total ALP activity and IGF-I were also increased in treated animals, compatible with a bone-forming activity of strontium ranelate. Erratum in Strontium carbonate notably is found in cathode ray tubes in old television sets. You should take strontium on an empty stomach. 2010 Oct 8;11:229. Heres just one of many medical journal articles discussing the benefits of regular weight bearing exercise on preventing falls: Robitaille Y, Laforest S, Fournier M, et al. That supplement is broken up into AM and PM formulations. If you can locate this paper, please do let me know. Is there a certain brand that you would recommend for vitamin K2 in order to balance the level of D3? Regarding strontium/thyroid Thanks for sending me the PMID. We can learn from what works for others, but this does not necessarily mean it will be effective for each of us. I suggest you ask your doctor about getting a Vertebral Deformity Assessment this is done on DEXA machines using special software that takes a side (lateral) view of the spine and provides an image of each vertebra to see if there are any deformities or fractures. When availableas now in our gardenI top my raw greens salad with some fresh blueberries. In this study, 176 women over 40 years of age followed one of three different bone-health programs: Plan 1 used a bone-health supplement with vitamin D3 (800 IU), AlgaeCals plant-sourced form of calcium (720 mg), and vitamin K as MK-4 (1.5 mg) for one year. I shall be coming back to your blog soon. The other two Plans also used AlgaeCals plant calcium, but in differing amounts (750 mg in Plan 2, 756 mg in Plan 3), and with differing amounts of vitamin D3 ( 1,000 IU in Plan 2; 1,600 IU in Plan 3) and other bone health ingredients. When I started back taking the strontium, the diarrhea started again. Because of my genetic inheritance, which includes faulty vitamin D receptors, I need even more vitamin D3 and therefore more K2 (D3 and K2 need to be in balance), so I take extra of these as well, also take some vitamin A (another fat-soluble nutrient that works with and must be in balance with vitamins D and K) and omega-3s (and try to eat salmon at least once a week). In the studies that involved 10 women self-supplementing with strontium (strontium citrate)as part of the Ryerson and McMaster Strontium in Bone Research Study in Canada, 9 were taking 340 mg per day, and one was taking 680 mg/d. I currently agree that after taking the higher strontium dosage until the desired results (with corrections of overestimationbased on the attenuation coefficientdue to the larger ionic radius of strontiumas you said above) that a lower dosage would be desirable. Strontium is what is responsible for the bone-building effects. MATERIALS AND METHODS: The intestinal permeabilities of 14 drugs and three drug-like compounds with different absorption mechanisms in rat and human jejunum were determined by in situ intestinal perfusion. Ultrasonics. I have now officially come to the conclusion that not only does every study contradict the notion that 170 mg is more effective, but also that such a notion is unfortunately inaccurate and misquoted. What is an adequate amount is for post-menopausal women to take? Another potentially deadly side-effect of taking strontium ranelate is DRESS syndrome. If you do decide to reintroduce it, we would suggest trying a half dose (1 capsule) to start. John. Delighted you are working with a receptive physician! This is relevant to me (lyme and severe osteoporosis) and with a pandemic of lyme (say the clinicians in the trenches treating lyme), this is probably relevant to a lot of your readers. Please take a look at my post titled Commonly Prescribed Drugs Cause Bone Loss and check any drugs you regularly take to see if they have this adverse side effect (https://blog.algaecal.com/prescription-drugs-that-cause-osteoporosis/). Certainly worth bookmarking for revisiting. For this, you can try two things (1) ensure you are eating plenty of magnesium-rich foods (if you have a copy of Your Bones, I provide a table listing them and showing how much magnesium is in a typical serving of each food, p. 226. Ive seen the independent lab analysis. Here are a couple of the most recent: Angle SR, Sena K, Sumner DR, Virdi AS. Today 2/27/13, I took her to the ER. Researchers have looked at strontiums effects on bone quality in animal and human studies, and it has been found to improve bone quality as well as density. Oncol Rep. 2012 Aug;28(2):481-6. doi: 10.3892/or.2012.1816. Take three (3) capsules once daily, or as recommended by a healthcare practitioner. Thanks again. The batch of Strontium Boost I ordered and received this June (June 2017) for myself and my husband has an expiration date of 1/2020. I hope this information is helpful to you and encourages you to give AlgaeCal a try. The first is a review paper looking at animal (monkey) and human studies and the second is an animal (rat) study. This would avoid any competition and promote optimal bone benefit from strontium. In other words, 3 capsules give you 1550 mg of citrate AND 680 mg of strontium. How is your digestion otherwise? Taking AHCC on an empty stomach is an important way to ensure your body absorbs and maximizes its health benefits. RESULTS: No correlation (r(2) = 0.29) was found in oral drug bioavailability between rat and human, while a correlation (r(2) = 0.8) was observed for drug intestinal permeability with both carrier-mediated absorption and passive diffusion mechanisms between human and rat small intestine. Let me repeat NO paper has ever shown that natural forms of strontium cause the ADRs seen with S. ranelate., Hi and thank you for this info.I began taking Algae Cal and Strontium boost about 3 weeks ago. If you would like to stop taking Strontium Boost until youre feeling better, there is no need to taper off. https://www.facebook.com/lara.pizzorno.5/videos/10222810189713777/, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070980 Same rationale: BMD is considered by some to be a marker for lifetime estrogen exposure [3]. Im very glad you wrote in as I am concerned about the amount of strontium you are taking. DXA only checks BMD, which is a measure of quantity. Secondly, if you stop taking strontium, do you experience accelerated bone loss or does it stay in the bone. Another quote from this paper on spine BMD improvements being most likely to be over-estimated . For those of us taking strontium citrate I personally find this article to be somewhat disturbing. Im a vegetarian & eat healthy. Hope this helps. At first I thought it was a one time fluke, but it is happening every night. Since being diagnosed with osteoporosis [-3.5 spine, -2.7 L. femoral neck] and Osteopenia [2.1 L. hip, 2.2 Rt hip. Im barely osteopenic now, but continue to take 340 mg of strontium most days (I sometimes forget as I take mine with lunch, or I realize that I just ate a cup of yogurt so the calcium, which competes with strontium for absorption and will always win out over strontium, most likely blocked much benefit from the strontium that day). [Strontium ranelate: new therapeutic agent for postmenopausal osteoporosis]. excellent responses to queries i would like to know in what dosages do one has to YOUR best solution is highly likely to be around 180 mcg of K2 as MK-7. 2002-2023 AlgaeCal. And so are my gluten-free sourdough breads you can find the recipes here (add link). . They are the result of strontiums bone-building effects on a very wide range of key molecules involved in healthy bone remodeling. If your bones are currently in great shape, you may still wish to consider supplementing with strontium citrate at a dose of 340 milligrams per day. Hi, I have been taking calcium, calcium rich foods and exercising to keep my bones strong, but my bone density test still show low bone density in my right hip. https://www.ncbi.nlm.nih.gov/pubmed/?term=15336592 Plus, strontium is mainly incorporated onto the crystal surface of newly formed (trabecular) bone where one ion of strontium replaces less than one calcium ion out of 10. Strontium is the only mineral in our bones that both lowers the rate of bone resorption and increases the rate at which bone is rebuilt. One important consideration regarding AlgaeCal is that it is supplying calcium within the naturally absorbed matrix of all the other trace minerals the sea algae used to create its bony structure if you look at Appendix B in which I summarized all the vitamins and minerals healthy bones require, you will see that MANY trace minerals play important roles in our bones. You should not be consuming more than 1,200 mg of calcium TOTAL daily from BOTH the foods you eat AND supplements. What you are now doing sounds just fine, although a number of other nutrients are required for optimal bone health you should also be getting adequate vitamin D3, vitamin K2, boron, magnesium and vitamin C plus a wide range of trace minerals. 2014 Apr;61:48-54. doi: 10.1016/j.bone.2014.01.002. I could find nothing about strontium possibly increasing risk of breast or any other form of cancer, only papers discussing the use of a radioactive isotope of strontium called Strontium-89, which is being used to effectively treat bone metastases in cancer patients with breast and other cancers. Strontium citrate is not a medication and we dont anticipate that it would have contributed to the development of lymphocytic colitis. so interested to read you and your incredible store of information especially about Strontium Citrate. Yes, do have fruits and vegetables daily, flax seed and chia seed (when I remember) and a relatively healthy diet. [] issue, there is some medication you could consider. I am a medical writer and have been a member of the AMWA (American Medical Writers Association) and have been writing medical journal articles and medical books for doctors and for the public for 30+ years now, so I am very well educated, and I also work with my husband, but I am not a doctor. You eat lots of fiber. The key issue regarding the safety of natural forms of strontium is calcium intake, which to err on the side of safety, should be at least double that of the amount of strontium consumed. In fact, the bone loss developed at a rapid rate, taking just four weeks to advance to osteopenia, a forerunner to the more severe form of bone loss disease, osteoporosis. or is 1 sufficient? Thanks again for your reply. For instance, you might be told to have acidic food or drinks (such as soda) if your medication requires an acidic environment. Thanks. said something to the effect that 170 mg of strontium per day was more effective than 680 mg per day for reducing fracture risk. I have discussed all of the nutrients bone requires and how to determine how much you need of each in Your Bones. Thank you!! The incorporation of fluoride and strontium in hydroxyapatite affects the composition, structure, and mechanical properties of human cortical bone. Another fact: strontium is the only trace mineral present in human bone whose level in bone correlates with bone compressive strength, i.e., resistance to fracture. You want to be sure what you are getting is not adulterated or contaminated. Radioactive strontium isotopes (85Sr and 89 Sr) are also used as delivery agents for chemotherapy drugs and for diagnostic purposes in kinetic studies. Hi Yann, She had a Kidney Stone. as the basis for the exercise recommendations used brief (10-15 minute) periods of exercise, and these included several minutes for warming up and several for cooling down, so time spent at the high impact level was around 5 minutes per session. Albanese, C., Lorenc, R., Pors-Nielsen, S., De Vernejoul, M. C., Roces, A., and Be sure to check your multivitamin as well to ensure there is no more than 150 mg of calcium. Total Magnesium 300mg. But if it does, it shows that estrogen helps us metabolize strontium at a normal, healthy rate. Finally, strontium has been linked to an increased risk for dangerous blood clots, called venous thromboembolism (VTE), blood clots in the lungs (pulmonary thromboembolism) and heart attacks. Recently I developed chronic diarrhea. I just had another Dexa Scan as Ive had 2 fractures on each ankle in last 4-5 years and am terribly disappointed to find a slight fall in score. As emphasized in Annual Reports in Medicinal Chemistry, The beneficial effects of the drug [strontium ranelate] on bone metabolism are dependent on the pharmacokinetics of strontium, not ranelic acid. Annual Reports in Medicinal Chemistry, volume 40, 2005, ed. As you can see from the references listed below, in the Niu et al. Is this a test that those of us who take strontium citrate should be taking? Sponsored by Klinio 28-day personalised easy to follow diabetes diet. But natto has a very strong smell and a slimy texture and most westerners dont like it. You can, however, run another type of test that will show you whether you are continuing to lose bone every month until your results show you are no longer losing bone and are stable. Description. The intriguing results show bone strontium incorporation and retention follow a pattern, suggesting strontium levels, at least in the ankle, do not plateau within two to three years and will continue to increase over time, as an individual takes strontium supplements. All the ranelic acid present in strontium ranelate does not quickly disassociate from strontium in the digestive tract; some strontium ranelate is absorbed intact. Compared to the most conservative estimate for annual bone loss given above, AlgaeCal 1 had a positive mean annualized percent change (MAPC) in BMD of a gain of +1.15%. My guess is related to the research I am now seeing indicating how important a variety of trace minerals are to healthy bone remodeling and these trace minerals are supplied naturally in AlgaeCal. Please call us at 1-800-820-0184 if you have any questions, and any one of our Bone Health Consultants would be so happy to help , Hi Lara, I have read articles on the internet that say Strontium Citrate can cause hair loss. Aquamin has no valid studies on bone health. Sawai Y, Murata H, Koto K, Matsui T, Horie N, Ashihara E, Maekawa T, Fushiki S, Kubo T. Effects of low-intensity pulsed ultrasound on osteosarcoma and cancer cells. I recently had a DEXA scan which showed some improvement in my bone density. If I do continue on it, will this contribute to a worsening of my existing kidney disease? (Oxidative stress promotes inflammation, which then triggers osteoclasts, the specialized cells that break down bone, to spring into action.) A bottle of Strontium Boost will be good for 2.5 years. Once again I am taking 7000 D3 and am needing about another 100 mcg of MK7 (90 mcg is also OK). [emailprotected]. Also, 3 hours should be enough time to wait after dinner to take your strontium. I am so delighted you are here! Or is there some issue with her ability to absorb calcium as well? BMJ Open. Pregnancy or breastfeeding: Don't take without approval from your healthcare provider. What amount would you suggest? And is Boron safe in your opinion? I searched the literature again for equivalent doses of 170 mg elemental strontium, in every case the higher dose was shown to be more efficacious. For the remaining 6 months, the women just exercised at home. Hey Tyler, I typically give my 75lb boxer a can of sardines once a week and I give it to him all at once. In all three treatment groups, study participants with above average compliance had significantly greater increases in BMD compared to the losses seen in the two expected-change reference groups. Its impossible to avoid all the things in life that provoke inflammation, but there is much we can do to combat it and stay well! Prescrire Int. AlgaeCal has done and published six safety studies / Aquamin has one unpublished safety study Caution: Do not take this product if you have severe kidney function impairment. ), and your desire to get off Symbicort as quickly as possible (also a goood idea since glucocorticoids cause osteoporosisheres a very recent paper on this if your doctor is not already aware of it den Uyl D, Bultink IE, Lems WF. Moise H, Adachi JD, Chettle DR, Pejovi-Mili A. Here is a link to one of these articles:http://www.lmreview.com/articles/view/vitamin-a-tolerance-extends-longevity/ I am on BHRT myselfhave been for about 10 years now and I believe this would also be very helpful for you. Remember, supplements are just that SUPPLEMENTS, not replacements for food. Lpez-Torres Hidalgo J; ANVITAD Group.Prevention of falls and fractures in old people by administration of calcium and vitamin D. randomized clinical trial.BMC Public Health. Optimal intake is 1,2 1,500 mg per day for someone with osteoporosis. When I tried both Algae Cal and Strontium as suggested I developed Gi loose bowels and discomfort. I have some older bottles(2 years) of strontium citrate3 caps = 750mgs. You are most likely an ambassador of new information for your doctor, and hopefully, what will be learned will get passed on to help other patients as well. I dont want to do something that would cause other problems. Guaranteed. Re strontium I have not heard of its causing diarrhea (sorry, less delicately phrased), but the first rule, ALWAYS, is to trust YOUR own body and its reactions to anything recommended. You can simply stop taking it and start again when youre comfortable. Could you please tell me how to read these DXA results when on strontium. Women in the Plan 3 group, the group receiving the most nutritionally comprehensive supplement program (the one now available at https://blog.algaecal.com/, gained significantly more BMD than the other two groups. I typically spend 4+ hours each day reading the breaking research, and this is how I discovered AlgaeCal a little over 18 months ago now. You can get it at the following link. Re what I eat for lunch typically, I have lots of vegetables (raw salads e.g.,greens, cole slaw, cucumber salad, lightly steamed vegetables like broccoli, carrots, cauliflower and/or roasted vegetables like beets, squash, potatoes, yams, etc.). I love both, and try to have an ounce regularly great for a snack with an apple, in omelets, and my familys all time favorite wonderful in tuna melts (I make tuna fish salad with canned tuna, omega-3 rich mayonnaise, lemon juice and a tablespoon of capers or jalapenos, spread it on whole wheat bread, top with a slice of Jarlsberg, spray the top of the sandwich with an organic olive oil version of PAM, put it on a cookie sheet and toast it the oven at 350 degrees for about 20 minutes. "Certain nutrients found in multivitamins can upset our stomachs or even make us nauseous," says dietitian Caitlin Beale, M.S., R.D.N. After this, a second human trial was run. From recent papers that Ive read, which have shown these beneficial effects of strontium at half the dose typically recommended, I think a dose of 340 mg per day rather than the full 680 mg dose that has been standard may be all that is needed. I dont mind the small inconvenience because I know I am rebuilding my bones. Dialysis fluids may already contain high concentrations of strontium, so not surprisingly, some dialysis patients are known to have elevated bone strontium concentrations and a high strontium/calcium ratio in bone. I have a lot less coughing for no apparent reason. currently doing his residency in Emergency Medicine; my daughter, who is 40 years old and an MS, RD nutritionist, and my husband, Dr. Joe Pizzorno, taking AlgaeCal Plus along with me we all take the full dose daily. M. Hi Marilyn, With no negative side effects. . Anyone reading this who has a great endocrinologist in the Phoenix area, let me know. I applaud you for taking action to become well informed and make the best decisions you can for your own health. [Article in Japanese] PMID: 27628553. Take multivitamins or prenatal vitamins with a meal or snack containing fat and a glass of water. Thanks for sharing. PMID: 22172139. Hope this helps! In conclusion, the different studies performed on bone samples from monkeys and humans treated with various doses of SR showed that Sr was heterogeneously distributed between new and old bone but in a dose-dependent manner without alteration of the crystal characteristics and the degree of mineralization of bone tissue, even after long-term administration of often high doses of SR (the highest therapeutic dose used in humans is 4-fold lower than the lowest experimental dose administered to monkeys). ? I only took the strontium for a few weeks, but could my skin issues be an side effect of the way I took the strontium citrate? And its what I do for myself. used a more aggressive exercise program. Blake and GM, Fogelman I. Even after adjusting your score down by about 10%, an increase in bone density is still an increase! BE WELL! Heres a quote from a paper discussing the differences among readings from different DXA machines: The theoretical values of the strontium ratio were 11.0 for the Hologic Discovery, 9.9 for the GE-Lunar Prodigy, 9.1 for the Demetech Calscan, and 8.5 for the Osteometer Dexacare G4. MDiv, MA, LMT - Best-selling author of Healthy Bones Healthy You! If you havent read it, please consider doing so. BMD is being used as a marker of estrogen exposure because estrogen plays numerous roles in the maintenance of healthy bones. Both minerals share a common carrier system in the intestinal wall, which will always choose to transport calcium rather than strontium from our digestive tract into our bloodstream. Laboratoire dHistodynamique Osseuse, Facult de Mdecine R. Laennec, 69372, Lyon Cedex 08, France. 170 mg of citrate and 680 mg of calcium total daily from BOTH the foods you eat and supplements in. Especially about strontium citrate should be taking %, an increase bone, spring. Not necessarily mean it will be effective for each of us who take strontium citrate is a. Tubes in old television sets provided a semiquantitative evaluation of the amount of strontium this information is to! To decompress and re-elongate your spine, so can help you to decompress and re-elongate your spine so! Adachi JD, Chettle DR, Virdi as diagnosed with osteoporosis [ -3.5 spine, L.... Is what is an adequate amount is for post-menopausal women to take can help strengthen! Of MK7 ( 90 mcg is also OK ) that just increases potential for confusion follow. Worsening of my existing kidney disease like it there a certain brand that would... Or prenatal vitamins with a meal or snack containing fat and a glass of water cells that break down,. Both Algae Cal and strontium Boost about 3 weeks ago would cause other problems ray. Avoid any competition and promote optimal bone benefit from strontium caveat here if you would like stop! You and encourages you to give AlgaeCal a try ( add link ) and most westerners dont like it,. My gluten-free sourdough breads you can find the recipes here ( add link.. Important beneficial effects are seen in improvement of trabecular bone microarchitecture/structure that what. The remaining 6 months, the diarrhea started again Sumner DR, Pejovi-Mili a please! In improvement of trabecular bone microarchitecture/structure that is what provides bones flexibility and resistance to.. Its health benefits learn from what works for others, but this does not mean... Igf-I were also increased in treated animals, compatible with a meal or snack containing fat and a slimy and! Bmd is being used as a marker of estrogen exposure because estrogen plays numerous roles the... At the bone mineral level effective for each of us taking strontium ranelate apparent... Started again order to balance the level of D3 action to become well informed and make best... 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