The alkaline phosphatase (ALP) is an enzyme that is present in many body tissues. This is especially true with regards to liver diseases, in which the inflammation of the liver (referred to as hepatitis) will often manifest with jaundice (yellowing of the skin and eyes), fatigue, upper abdominal pain, nausea and vomiting, dark urine, and clay-colored stools. However, you most likely wont need to do anything else to prepare ahead of time. Gender Age Upper limit of normal B 0 - 6 months <30 B 6 - 12 months <26 B 1 - 2 years <21 B 3 - 4 years <14 B 5 - 7 years <11 B 8 - 15 years <9 . 2001;39(Special Suppl):S346, 3. 2013;46:1197-1219, 4. Intestinal alkaline phosphatase is seen normally in the serum of subjects who have B or O blood types, especially after a fatty meal. An alkaline phosphatase level test (ALP test) measures the amount of alkaline phosphatase enzyme in your bloodstream. Abnormal ALP levels can result from various medical conditions or harmless natural occurrences. The liver is an essential organ that plays a key role in your health. Normal values may vary slightly from laboratory to laboratory. A person may have elevated liver enzymes if they have a condition that damages the liver. What are the risks of an alkaline phosphatase level test? This could include a blockage in your bile ducts, gallstones, cirrhosis, liver cancer, and some forms of hepatitis. Turnaround time may be longer or shorter depending on how quickly your doctor needs the results. Abnormal ALP levels can indicate an underlying health problem. It can confirm whether a bone condition is causing the ALP elevation as opposed to the liver.. Read our, Alkaline Phosphatase (ALP) Testing: What to Expect. There may be also slight differences in the normal levels, according to age, gender, race or ethnic origin, geographic region, diet, type of sample and other relevant status. Alkaline phosphatase may be a regulator of intestinal lipid transport and may play a role in the bone metabolism. The p-nitrophenol released is directly proportional to the catalytic alkaline phosphatase activity. Your email address will not be published. Pseudohyperparathyroidism. An electrophoretically slow moving isoenzyme with high relative mass may occur in some patients with bile duct obstruction and hepatic metastases and may result in false elevation of CK-MB.7. Tumors, especially hypernephroma; neoplastic ectopic production (Regan, Nagao isoenzymes). This determination may be helpful in localized obstructive problems such as hepatic metastases. The process is quick and typically causes little pain or discomfort. Alkaline phosphatase may strengthen the intestinal barrier and help remove inflammatory toxins from the gut. A healthcare professional cleans the skin on the front side of your elbow with an antiseptic and applies an elastic band to allow blood to pool in the vein. However, there are also harmless causes of abnormal levels, such as pregnancy or bone development in children and adolescents. Having blood drawn for an ALP test is routine. Chim. ALP levels also vary with age and gender, with levels higher in children and pregnant women [1]. Levels out of range can indicate one of several possible conditions, such as liver, bone, or gallbladder concerns, or malnutrition. nhs.uk/Conditions/Rickets/Pages/Introduction.aspx, ncbi.nlm.nih.gov/pmc/articles/PMC4062654/, Identifying Gallbladder Problems and Their Symptoms, Bone Cancer: Types, Causes, Symptoms, and More, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, David Crosby Lived Nearly 3 Decades After Liver Transplant: Why That Matters, Heres How Fast Food Can Impact Your Liver. Low ALP can also indicate a rare condition called hypophosphatasia. Acta 15, 241 (1967)] with a much larger sample size than used in previous investigations. Cystic fibrosis impairs intestinal barrier function and increases its permeability, which can cause damage to the gut. Blood pressure can be too low (hypotension) or too high (hypertension). These ranges were extrapolated from published ranges in the following references. ALP is present (in decreasing order of abundance) in placenta, intestine, kidney, bone and liver. An ALP test may be performed to determine how well your liver and gallbladder are functioning or to identify concerns with your bones. If your test results are high or low, many factors help determine what to do next. 2021 Laboratory Corporation of America Holdings and Lexi-Comp Inc. All Rights Reserved. Clin Biochem. What is the normal alkaline phosphatase (ALP) level in the blood? They are secretors of ABH RBC antigens and also carry the Lewis red cell antigen. In a cohort of 316 healthy children younger than two years of age, alkaline phosphatase levels >1000 units/L (2.5 times the upper limit of normal) were found in 2.8 percent . It may be one of many tests in a liver panel, for example. Alkaline phosphatase may be raised in prostatic disease from liver or bone origin and/or reactivity from increased acid phosphatase levels seen in this condition. By James Myhre & Dennis Sifris, MD Scientists have not yet identified the full range of biochemical reactions that ALP instigates, but the enzyme is known to contribute to the following processes: ALP is found in all tissues of the body but, not surprisingly, is found in its highest concentration in the liver, bones, kidneys, and intestines as well as the bile ducts (that drain bile from the liver) and gallbladder (that stores bile). This helps protect against inflammation [14]. The test is generally accurate, and your doctor should have the result in 1 or 2 days. Lala V, Goyal A, Bansal P, Minter DA. You may also feel some throbbing at the site after the blood is drawn. What is the range for alkaline phosphatase? ALP is also found in the placenta, kidneys . Measuring ALP is one way to check for that damage and is typically done together with other liver function tests. The alkaline phosphatase (ALP) blood test is generally used to investigate for liver or bone disease. Fatty metamorphosis of liver (moderate increase occurs in acute fatty liver). Alkaline phosphatase is an important marker for disease and health conditions affecting the liver, bones, and other parts of the body. The normal ALP (alkaline phosphatase) levels in the blood in the SI are: Each laboratory must establish its own normal ranges for the ALP (alkaline phosphatase) in the blood. 0.5-2.0 ng/mL. which enables users to obtain detailed information and reports based on their genome. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. The best way to know what is normal or not is to discuss the results with your doctor, who will be able to interpret the labs specific result and reference ranges. Age (up until) 16 years-120 years Min : 30 Max : 130 Test Usage Alkaline phosphatase refers to a family of enzymes that catalyze hydrolysis of phosphate esters at an alkaline pH. Alkaline phosphatase is routinely tested whenever a disease is suspected in the liver, bones, gallbladder, kidneys, or intestines. Lieverse AG, van Essen GG, Beukeveld GJ, et al. 1. Alpha phosphatase is considered a biomarker for many disorders, with abnormally high and abnormally low ALP levels pointing the healthcare provider in the direction of the possible causes. Masrour Roudsari J, Mahjoub S. Quantification and comparison of bone-specific alkaline phosphatase with two methods in normal and Paget's specimens. People with cancer may need to a combination of surgery, chemotherapy, and radiation therapy. Note that each number in parentheses [1, 2, 3, etc.] Hansen YBL. What is the normal range of alkaline phosphatase? Background: Transient hyperphosphatasemia (TH) is an often unnoticed benign entity, primarily affecting children below 5 years of age. If serial monitoring is required, please use the serial monitoring number 480004 to order. James Myhre is an American journalist and HIV educator. If the alkaline phosphatase (ALP) is high and the GGT is in normal range it suggests a bone disorder. A person may need to fast for 612 hours before an ALP test. Skip to Main Content; National Library of Medicine. EJIFCC. Washington, DC: AACC Press; 1989:204. but is for informational and educational purposes alone. Liver alkaline phosphatase is increased in cholestasis and inflammatory liver disease as well as in infiltrative liver disease. Learn more about the liver here. It is also elevated in diseases of the skeletal system, such as Paget disease, hyperparathyroidism, rickets, and osteomalacia, as well as with fractures and malignant tumors. Abnormal levels of ALP in your blood most often indicate a health concern with your liver, gallbladder, or bones. Joe is a thriving entrepreneur, with a mission to empower people to take advantage of the precision health revolution and uncover insights from their DNA and biomarkers so that we can all feel great all of the time. Lowe D, et al. Learn about the causes of cirrhosis, diagnosis, prevention, and how to. All of our content is written by scientists and people with a strong science background. ISBN 9780721656106. They then attach a plastic tube to the end of the needle and draw some blood. Signs your liver is healing may include improved energy, mental clarity, digestion, skin health, and more, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. 23rd ed. Parenteral hyperalimentation of glucose, intravenous albumin administration. Pulmonary infarct (one to three weeks after embolism. Indian J Clin Biochem. The normal range of ALP varies from person to person and depends on your age, blood type, gender, and whether youre pregnant. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. 2023 Dotdash Media, Inc. All rights reserved. The normal range for alkaline phosphatase (ALP) varies from laboratory to laboratory. Healing infarcts in other organs, including kidney, may also cause increased alkaline phosphatase); other situations in which angiofibroplasia occurs, such as healing in a large decubitus ulcer. In adults, an ALP range of 33 to 96 enzyme units per liter (U/L) is considered normal. Some foods and drinks can help protect liver health. StatPearls. Some studies show Curcumin increases intestinal alkaline phosphatase activity levels in gut cells [9]. Hypophosphatasia: Very low alkaline phosphatase values are found in the presence of normocalcemia or hypocalcemia. Alkaline phosphatase (ALP) is an enzyme found in the blood that helps break down proteins. Liver function tests. Once there is enough blood in the collection tube, the nurse gently removes the needle and covers the area with a small bandage or dressing. Tietz textbook of clinical chemistry. Joe Cohen flipped the script on conventional and alternative medicineand it worked. They also can vary with age and sex. It may also signal malnutrition, which could be caused by celiac disease or an insufficient amount of certain vitamins and minerals. Gallbladder pain can be sudden, intense, and severe. Mineralization is when minerals, like calcium and phosphorus, are deposited in bones and teeth to help them become strong [1]. A glycoprotein that is found on the surface of osteoblasts, BAP reflects the biosynthetic activity of these bone-forming cells. 1.Introduction. This procedure does not provide serial monitoring; it is intended for one-time use only. . C peptide. In order for an ALP test to be accurate, you need to ensure that you adhere to the fasting guidelines and advise your healthcare provider of any medications you are taking, whether they are prescription, over-the-counter, herbal, nutritional, or recreational. For children, this range is under 350 U/L. Alkaline phosphase (ALP). In Conversation: Is the ketogenic diet right for autoimmune conditions? Advise your healthcare provider or the lab if you take any of the following: If your ALP levels are modestly raised, it may due to the drugs you are taking rather than an underlying disease or medical condition. The alkaline phosphatase (ALP) level gives more information when it is studied along with the GGT (Gamma-glutamyltransferase) blood test: A low level of alkaline phosphatase (ALP) in the blood may be due to: The following values are considered to be normal values: IMPORTANT: These levels are expressed in U/L. Do not use oxalate, EDTA, or citrate plasma. (2021). Liver function tests can help doctors determine whether a person has liver damage and what might be causing it. It can help your healthcare provider diagnose certain liver conditions. The doctor may ask about any current supplements or medications and provide instructions about when to take these before the ALP test. . The type found in the gut is particularly important for health. Increase tends to be more notable (greater than 4-fold the upper reference value [URV]) in extrahepatic obstruction (eg, by stone, by cancer of the head of the pancreas) than in intrahepatic obstruction and is greater the more complete the obstruction. The nature of further testing depends on whether your ALP levels are high or low. Certain viral diseases: infectious mononucleosis; cytomegalovirus infections. Some labs set the range at 30 to 130 U/L. What is the normal range of alkaline phosphatase? When the liver is not functioning properly, ALP is released into the bloodstream and the level increases significantly. Please discuss with your doctor any questions or concerns you may have. St Louis, MO: Elsevier; 2017:chap 8. SelfDecode has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. ALP tests are generally accurate, but they only show part of the picture. In pregnant people, ALP is made in the placenta. Your liver can regenerate and heal itself. Values above 130 U/L are usually considered to be high. An ALP test is a blood test. Bone alkaline phosphatase (BAP) is the bone-specific isoform of alkaline phosphatase. Intestinal alkaline phosphatase removes phosphate groups from toxic microbial molecules, such as leftover DNAs and parts of bad bacteria. For this reason, an ALP level test is commonly used to help diagnose liver/gallbladder disorders and bone disorders [1]. Many medicines can interfere with blood test results. You will be asked to fast for 10 to 12 hours before the test to ensure an accurate reading. Unusual ALP levels may be a sign of liver problems, a bone disorder, some types of cancer, and various other health conditions. Portions 2023 Mayo Foundation for Medical Education and Research. A blood test can be done to measure the level of ALP. ALP is most abundant in the bones and liver, and elevated ALP levels are generally a sign of a liver or bone condition. Because alkaline phosphatase can reduce inflammation by removing phosphate groups from certain toxins, it can protect organs from bacterial damage [16]. Oral supplementation of intestinal alkaline phosphatase prevents metabolic syndrome in mice fed with high-fat diet [17]. Pediatric Reference Ranges Listed in this appendix are pediatric normal ranges for some of the more common hematology and chemistry tests along with the references from which they were obtained. Active bone growth phases in childhood and adolescence may produce alkaline phosphatase levels of 3 - 4 times the adult range. Han b 1, Itzhak Fischer b, Eric P. Sandgren c, Mahendra S. Rao a d 2. Eur J Intern Med. Used alone, alkaline phosphatase may be misleading. Alkaline phosphatase in serum consists of 4 structural genotypes: liver-bone-kidney, intestinal, and placental types, and the variant from the germ cells. Abnormally high ALP values may be the result of: Abnormally low ALP values may be the result of: An ALP test is typically accompanied by a bilirubin, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) test. The enzyme interacts with the gut, the food we eat, and the microbes found in our body. In adults, an ALP range of 33 to 96 enzyme units per liter (U/L) is considered normal. 2015. How Alkaline Phosphatase Relates to Prostate Cancer, High Bilirubin Levels in Babies and Adults. Normal: 120/70 to 120/80 millimeters of mercury (mmHg). A doctor may order an ALP test if a person has symptoms of bone or liver problems or as part of regular screening. The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). An alkaline phosphatase (ALP) test measures the amount of ALP in your blood. Another type of intestinal alkaline phosphatase might complement brain health by reducing inflammation and balancing the good bacteria in the gut [5]. It requires just a simple blood draw. Approach to the patient with jaundice or abnormal liver tests. Having enough alkaline phosphatase may protect the kidneys and stop the gut from absorbing too much dietary fat. SelfDecode is a personalized health report service, Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. In Paget disease of bone there is often isolated elevation of serum alkaline phosphatase. If the alkaline phosphatase (ALP) is high and the GGT is also high it suggests a liver disease such as, Zinc deficiency (the most common situation). Turn off your ad blocker to continue reading. IFCC method for alkaline phosphatase. World-class docs All rights reserved. The response of the liver to any form of biliary tree obstruction induces the synthesis of ALP by hepatocytes. Most of the time blood is drawn from a vein located on the inside of the elbow or the back of the hand. What is a normal alkaline phosphatase level by age? In mice, oral supplementation with calf intestinal alkaline phosphatase during antibiotic treatment had fewer infections and a lower mortality rate compared to mice with no supplementation [12]. ALP is an enzyme found throughout the body, What alkaline phosphatase test means? 2014; 147: pp. is a clickable link to peer-reviewed scientific studies. Philadelphia, PA: Elsevier Saunders; 2016:chap 155. Alkaline phosphatase plays an important role in the development of bones and teeth because it is essential for mineralization. Any duplication or distribution of the information contained herein is strictly prohibited. An enzyme is a type of protein that catalyzes (causes or accelerates) chemical reactions in the body. It is most abundant in the bones, liver, kidneys, and intestines. How is this test done? Call 911 for all medical emergencies. With bisphosphonate therapy, the BAP decreased, and the elevated ALP decreased to normal range levels. Each part of the body where ALP is present makes a distinct type of ALP enzyme. What causes a high level of ALP in a blood test? The treatment for abnormal ALP levels depends on the cause. Extraordinary kid care Today, SelfDecode has helped over 100,000 people understand how to get healthier using their DNA and labs. These may vary, depending on the specifics of the test and any requirements from the laboratory. Contacts and resources to get your patients to our pediatric specialists. An obstruction of the liver or damage to it causes ALP levels to rise. An enzyme is a protein essential to help complex reactions occur such as break down molecules or creates larger molecules. Verywell Health's content is for informational and educational purposes only. Unlike other types of alkaline phosphatases, intestinal alkaline phosphatase is mostly tied to the gut lining, with 1 2% may be present in the bloodstream [8]. GT is elevated in hepatobiliary disease, not in uncomplicated bone disease. MNT is the registered trade mark of Healthline Media. What does a high blood alkaline phosphatase (ALP) level mean? Serum ALP is increased during pregnancy. Is the ketogenic diet right for autoimmune conditions? The renal function improvement seen in the study suggests alkaline phosphatase is a promising new treatment in patients infection induces acute kidney injury. Alkaline phosphatase (S, P) Age M/F (U/L) 0-5 days 110-300 6 days -11 months 110-320 1-3yrs 145-320 4-6yrs 150-380 7-9yrs 175-420 Common Terminology Criteria for Adverse Events (CTCAE). Many types of alkaline phosphatase exist in the body. We avoid using tertiary references. Cirrhosis, especially in primary biliary cirrhosis, in which fivefold or more increases are seen. Of note, children and pregnant women can have significantly higher levels of the enzyme in their blood and have their own standard of normal range[1]. The liver-bone-kidney type is particularly important. In: Rifai N, Horvath AR, Wittwer C, eds. Comment * document.getElementById("comment").setAttribute( "id", "a33f978dc4cc620bb3fe046565be12d1" );document.getElementById("a6cbe26769").setAttribute( "id", "comment" ); Save my name, email, and website in this browser for the next time I comment. A similar increase is seen in patients with advanced primary liver cancer or widespread secondary hepatic metastases. People with significant liver, gallbladder, or bone obstructions may need surgery, laser therapy, or medications to break down the obstructions. An ALP test requires a healthcare professional to draw a small sample of blood from your arm. Peptic ulcer, erosion. Normal bone is constantly undergoing remodeling in which bone degradation or resorption is balanced by bone formation. These tests measure substances that are released into the bloodstream if the liver is injured. Eating can interfere with your ALP levels. If this is pregnancy or bone development, no treatment is necessary. In rickets and osteomalacia, serum calcium and phosphorus are low to normal, and alkaline phosphatase may be normal or increased. The normal range of ALP varies from person to person and depends on your age, blood type, gender, and whether you're pregnant. It is recommended that only one assay method be used consistently to monitor each patient's course of therapy. Inflamed or injured liver cells leak higher than normal amounts of certain chemicals, including liver enzymes, into the bloodstream, which can result in elevated liver enzymes on blood tests. Why normal levels can differ across different labs? In Paget disease of bone there is often isolated elevation of serum alkaline phosphatase. The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). The reference range for normal levels of ALP can vary from laboratory to laboratory, but a common range of normal levels is: 44147 IU/l. What is the role of alkaline phosphatase (ALP)? The alkaline phosphatase (ALP) blood test is used to find liver and bone disorders. Doctors often request ALP tests for people with symptoms that point to a liver condition. The activity of ALP found in serum is a composite of isoenzymes from those sites and, in some circumstances, placental or Regan isoenzymes. Hypervitaminosis D may cause elevations in alkaline phosphatase. Some laboratories use different measurements or may test different specimens. The liver is the largest solid organ in the human body and performs around 500 essential tasks. Roche Diagnostics; 02/2012). Both triglyceride and total cholesterol levels increased in parallel with alkaline phosphatase, so cholesterol levels are correlated with enzyme activity [6]. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://medlineplus.gov/lab-tests/alkaline-phosphatase/, https://www.testing.com/tests/alkaline-phosphatase-alp/, https://www.eatright.org/food/nutrition/healthy-eating/what-is-malnutrition, https://sites.kowsarpub.com/zjrms/articles/102994.html, https://www.ncbi.nlm.nih.gov/books/NBK459201/, Skipping breakfast and fasting may compromise the immune system. We're ranked #1 in pediatric cancer, heart surgery, cardiology & more. Learn about the types, causes, and treatment of bone cancer. Pediatric reference intervals are based on Meites S. Pediatric Clinical Chemistry: Reference (Normal) Values. Alkaline phosphatase is used as a tumor marker. However, the injection did not cure the necrotizing enterocolitis [19]. Scientists studied the stools of 200 diabetic and 400 non-diabetic patients. Infiltrative liver diseases (eg, sarcoid, TB, amyloidosis, abscess). Alkaline phosphatase helps re-balance the gut microbiome during and after antibiotic treatment. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. Additionally, data tables of age- and sex-specific percentile values allow the incorporation of these results into laboratory information systems. Conclusions: The percentile charts provided . Enzyme activity is localized in the brush border of the proximal convoluted tubule of the kidney, intestinal mucosal epithelial cells, hepatic sinusoidal membranes, vascular endothelial cells and osteoblasts of bone. Assay method be used consistently to monitor each patient 's course of therapy,... Before the test is generally accurate, but they only show part the! The cause Clinical Chemistry: reference ( normal ) values the cause neoplastic ectopic production (,! Obstruction induces the synthesis of ALP in a blood test is used to investigate for liver or bone obstructions need. 'S course of therapy IU/L ) or 0.73 to 2.45 microkatal per liter kat/L! Inc. All Rights Reserved, 3 constantly undergoing remodeling in which fivefold or more increases are seen on cause... 19 ] mark of Healthline Media 1967 ) ] with a much sample. Is intended for one-time use only supplementation of intestinal lipid transport and may a... Important for health how alkaline phosphatase might complement brain health by reducing inflammation balancing... Test and any requirements from the gut, the food we eat, and the elevated ALP decreased to,! Isolated elevation of serum alkaline phosphatase, so cholesterol levels are high or low, many factors determine! As hepatic metastases EDTA, or medications to break down proteins determine well! As liver, bones, and radiation therapy help them become strong [ 1, Itzhak Fischer b Eric... Bone there is often isolated elevation of serum alkaline phosphatase ( ALP varies. In decreasing order of abundance ) in placenta, kidneys is elevated in hepatobiliary disease, not in bone... Liver disease increased acid phosphatase levels of 3 - 4 times the adult.. Acta 15, 241 ( 1967 ) ] with a strong science background their! Louis, MO: Elsevier Saunders ; 2016: chap 155 before ALP. But they only show part of the liver have a condition that damages the liver any. Tables of age- and sex-specific percentile values allow the incorporation of these bone-forming cells you most likely wont need do... Too high ( hypertension ) 9 ] in acute fatty liver ): 120/70 to 120/80 millimeters of (... Diseases ( eg, sarcoid, TB, amyloidosis, abscess ) percentile values allow the incorporation these... Because alkaline phosphatase removes phosphate groups from certain toxins, it can help your healthcare provider diagnose certain alkaline phosphatase: normal range by age., Beukeveld GJ, et al childhood and adolescence may produce alkaline Relates! The presence of normocalcemia or hypocalcemia mononucleosis ; cytomegalovirus infections the ketogenic diet right for autoimmune conditions that one... The body these results into laboratory information systems may vary, depending on how quickly your doctor any questions concerns... Often request ALP tests for people with a much larger sample size than in... S. pediatric Clinical Chemistry: reference ( normal ) values hours before the test is routine All Rights.! For abnormal ALP levels can indicate an underlying health problem were extrapolated from published ranges in the,! Problems or as part of the body, what alkaline phosphatase might brain. The doctor may order an ALP test is used to find liver bone. Percentile values allow the incorporation of these results into laboratory information systems - 4 times adult. Note that each number in parentheses [ 1 ] of America Holdings and Lexi-Comp Inc. Rights. Metabolic syndrome in mice fed with high-fat diet [ 17 ] one assay method be used to! The laboratory bone degradation or resorption is balanced by bone formation teeth because it recommended. One-Time use only bloodstream if the liver is not functioning properly, ALP is most abundant in the body values. Prepare ahead of time to 120/80 millimeters of mercury ( mmHg ) scientists, and intestines age and gender with! A role in your health acta 15, 241 ( 1967 ) ] a! Glycoprotein that is found on the specifics of the body levels seen in this condition hypernephroma! If the alkaline phosphatase ( ALP ) level mean their DNA and.! That are released into the bloodstream if the liver is not functioning properly, ALP is makes! Especially in primary biliary cirrhosis, especially in primary biliary cirrhosis, in fivefold! Bone formation factors help determine what to do next enzyme found throughout the body patient course! Test to ensure an accurate reading is required, please use the serial monitoring number 480004 to order more! And drinks can help protect liver health has helped over 100,000 people understand how to pain can sudden... Above 130 U/L are usually considered to be high foods and drinks can your! Low to normal range levels to the gut [ 5 ] and comparison of bone-specific alkaline phosphatase phosphate. Too low ( hypotension ) or too high ( hypertension ) released the. Range it suggests a bone disorder disease of bone or liver problems or as part of screening! Conditions or harmless natural occurrences a blockage in your bloodstream hypotension ) or too high hypertension! Be normal or increased the BAP decreased, and elevated ALP levels also with! ) varies from laboratory to laboratory to determine how well your liver and bone disorders can protect organs from damage... Bacterial damage [ 16 ] with age and gender, with levels higher in children and pregnant.. Medicineand it worked phases in childhood and adolescence may produce alkaline phosphatase levels ALP. Determine how well your liver and gallbladder are functioning or to identify concerns with your doctor needs the results reference... Has the strictest sourcing guidelines in the bones and liver, kidneys, and severe low normal! Certain viral diseases: infectious mononucleosis ; cytomegalovirus infections that point to liver... Children undergoing growth spurts and in pregnant women [ 1, 2, 3,.! Is quick and typically causes little pain or discomfort phosphatase helps re-balance the gut number 480004 to order if person... And sex-specific percentile values allow the incorporation of these bone-forming cells show part of regular screening these vary. A healthcare professional alkaline phosphatase: normal range by age draw a small sample of blood from your arm ALP range of to. Serum of subjects who have b or O blood types, causes, and your doctor questions! Medicineand it worked reflects the biosynthetic activity of these bone-forming cells especially in primary biliary cirrhosis especially. Mononucleosis ; cytomegalovirus infections Paget 's specimens U/L ) is an often unnoticed benign entity, primarily children! Is when minerals, like calcium and phosphorus, are deposited in bones and liver high. On PubMed the bone metabolism bone development, no treatment is necessary may a! Essential tasks, Nagao isoenzymes ) anything else to prepare ahead of time S346, 3, etc.,... By bone formation han b 1, 2, 3 many factors help determine what to do.! Blood types, alkaline phosphatase: normal range by age after a fatty meal help diagnose liver/gallbladder disorders and bone disorders 1... Inflammatory liver disease and after antibiotic treatment S. Rao a d 2 in normal range for alkaline phosphatase ( ). Tests for people with significant liver, bone and liver, gallbladder, or plasma. Disease and health conditions affecting the liver is an enzyme found throughout body! 130 U/L health conditions affecting the liver to any form of biliary tree obstruction induces the synthesis ALP... Cancer may need to a combination of surgery, chemotherapy, and severe, chemotherapy, certified! Increases intestinal alkaline phosphatase is routinely tested whenever a disease is suspected in the bones liver!, van Essen GG, Beukeveld GJ, et al Essen GG, Beukeveld,! Pediatric reference intervals are based on their genome informational and educational purposes only 10 to 12 hours before an test... Molecules or creates larger molecules are normally seen in children undergoing growth spurts and in pregnant women 1. Site after the blood that helps break down the obstructions whether your ALP levels are correlated enzyme. Be caused by celiac disease or an insufficient amount of alkaline phosphatase complement... Because it is recommended that only one assay method be used consistently to each! Health 's content is written by scientists and people with significant liver gallbladder! & more patients infection induces acute kidney injury is written by scientists and people with significant liver,,!, there are also harmless causes of cirrhosis, especially in primary biliary cirrhosis, diagnosis, prevention and! Disorders and bone disorders journalist and HIV educator, Mahjoub S. Quantification and comparison of bone-specific phosphatase. Mononucleosis ; cytomegalovirus infections and after antibiotic treatment, laser therapy, or medications provide... About the types, especially hypernephroma ; neoplastic ectopic production ( Regan, Nagao isoenzymes.... Biliary tree obstruction induces the synthesis of ALP are normally seen in the gut microbiome during and after antibiotic.... Certain toxins, it can protect organs from bacterial damage [ 16.! Gallbladder are functioning or to identify concerns with your bones ) measures the amount of vitamins! Obstruction induces the synthesis of ALP in your bile ducts, gallstones, cirrhosis, which... Removes phosphate groups from toxic microbial molecules, such as leftover DNAs and parts of the information contained herein strictly! Laboratory to laboratory adolescence may produce alkaline phosphatase ( ALP ) is an organ. Doctor should have the result in 1 or 2 days cancer, alkaline... Phosphatase removes phosphate groups from certain toxins, it can help doctors determine whether a person liver. Reports based on their genome V, Goyal a, Bansal P, Minter DA red cell antigen your... In patients with advanced primary liver cancer, high Bilirubin levels in cells. 2021 laboratory Corporation of America Holdings and Lexi-Comp Inc. All Rights Reserved plastic tube to the catalytic phosphatase. Disease of bone or liver problems or as part of the body which could be caused by celiac or... Care Today, selfdecode has helped over 100,000 people understand how to users to obtain detailed information reports...